Mushrooms To Prevent Dementia?

2 min

It is true that a study published in January 2017 concluded that bioactive compounds found in certain mushrooms may help protect against Alzheimer’s disease. And other forms of dementia. The study, from Malaysia, found that a number of edible and medicinal mushrooms contain unusual compounds that have beneficial effects on brain cells. They may enhance nerve growth in the brain and protect against inflammation and oxidative damage that contribute to neurodegeneration.

The researchers looked at the effects of 11 mushrooms, including lion’s mane, maitake (also known as hen of woods), cordyceps, and eight other edible and medicinal species, investigating their effects on rat and mice brains. The study found that each one increased production of nerve growth factor, a molecule involved in regulating maintenance, proliferation and survival of specific nerve cells in the brain.

The researchers reported that the medicinal mushroom cordyceps (Cordyceps sinensis) had antioxidant and anti-inflammatory effects that prevented neuronal cell death and memory loss. Cordyceps is known for enhancing athletic performance and improving aerobic (lung) capacity. It is used to combat fatigue and muscle weakness, improve mental energy, increase sexual vigor, and promote healthy aging.

The study also saw potential in lion’s mane mushroom, (Hericium erinaceus), a medicinal (and culinary) mushroom believed to stimulate nerve growth. The researchers cited a double-blind, placebo-controlled trial published in 2009 showing that 50 to 80-year-old Japanese men and women with mild cognitive impairment improved after taking four tablets of lion’s mane mushroom 3 times a day for 16 weeks. Another Japanese study found that the same supplement taken 6 times a day for 4 weeks decreased anxiety and improved sleep among undergraduate students.

The researchers reported that reishi mushrooms, known for their anti-cancer and immune boosting properties, led to improved cognitive ability and increased longevity in rodents.

All this is excellent news. In part because of investigations such as these, many mushroom species are now considered functional foods, much like turmeric and green tea, which have been shown in other studies to exert neuroprotective and antioxidant effects on the brain.

As you may know, I’m a big fan of mushrooms, although I advise against excessive consumption of the familiar cultivated white or “button” mushrooms found on supermarket shelves throughout the United States. (Portobello and cremini mushrooms are the same species.) They contain natural carcinogens that are mostly but not entirely neutralized by cooking. Andrew Weil, M.D.

Learn more: All About Mushrooms

Source:
Chia Wei Pfan et al, “Edible and Medicinal Mushrooms: Emerging Brain food for the Mitigation of Neurodegenerative Diseases.” Journal of Medicinal Food, January 2017, DOI: 10.1089/jmf.2016.3740

Originally published April 2017. Updated September 2025.