Dense Breasts: A Breast Cancer Concern?

How would a woman know if she has dense breasts? I heard this is now considered the biggest risk of breast cancer.

– July 16, 2017

Dense breasts contain a lot of fibrous or glandular tissue and not much fatty tissue. The difference in composition shows up on mammograms and, according to the American Cancer Society, is not related to breast size or firmness. You can ask about your breast density after having a mammogram.

A study from the University of California, San Francisco published in February (2017) concluded that women who have dense breasts are at higher risk of breast cancer and that population-wide this risk is greater than having a family history of the disease, a personal history of benign breast lesions or no first pregnancy until after the age of 30.

The researchers looked at breast cancer risk factors in more than 200,000 women between the ages of 40 and 74 who were participating in a study to evaluate the delivery and quality of screening for the disease; 18,437 of them had some stage of breast cancer. The investigators calculated the effect of each risk factor by comparing the women with breast cancer to those of the same ages who were unaffected.

They noted that dense breasts are more common in younger women and that breasts become less dense during and after menopause, unless women are on hormone replacement therapy. The study assessed breast density for the women in the study via a rating system established by the American College of Radiology.

This ranks breast composition as:

(A) Almost entirely of fat

(B) Mostly fat with scattered dense tissue

(C) Moderately dense tissue

(D) Dense tissue that makes up at least 75 percent of the breast.

The team suggested that 39.3 percent of breast cancers in pre-menopausal women and 26.2 percent in post-menopausal women might have been prevented if all the women with higher breast density had breasts composed almost entirely of fat or mostly fat with some scattered dense tissue.

Although overweight and obese women are more likely to have fatty breasts, the study found a higher breast cancer risk among postmenopausal women with a high body mass index. This is in keeping with earlier findings that being overweight or obese increase the risk.

There’s not much you can do to reduce your breast density. The drug tamoxifen, which blocks estrogen and is used to prevent breast cancer recurrence, can help. However, Natalie Engmann, the study’s first author, noted that tamoxifen can have serious side effects and is generally recommended as a preventative measure only for women at high risk.

I’m sure we’ll be hearing more about breast density and the extent of the cancer risk it poses. In the meantime, your best bet is to focus on the risk factors you can modify. Here are six ways to minimize risk of breast cancer.

 

Andrew Weil, M.D.

Source:

Natalie J. Engmann et al, “Population-Attributable Risk Proportion of Clinical Risk Factors for Breast Cancer.” JAMA Oncology, February 2, 2017, doi:10.1001/jamaoncol.2016.6326

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