• Weil Nutrition Corner
  • Meet Dr. Weil
  • Origins
  • Healthy Aging
  • Marketplace
  • Podcasts
  • Accessibility
  • Subscribe
Dr. Weil Logo Dr. Weil Logo Weil™ Andrew Weil, M.D.
  • Health & Wellness
    Health & Wellness
    Body, Mind & Spirit
    • Addiction
    • Allergy & Asthma
    • Autoimmune Disorders
    • Back Pain
    • Bone & Joint
    • Cancer
    • Colds & Flu
    • Dental & Oral
    • Diabetes
    • Disease & Disorders
    • Ears, Nose, & Throat
    • Feet
    • Gastrointestinal
    • Hair, Skin, & Nails
    • Headache
    • Heart
    • Insects & Parasites
    • Liver & Kidney
    • Mental Health
    • Pregnancy & Fertility
    • Respiratory
    • Sexual Health
    • Sleep Issues
    • Stress & Anxiety
    • Vision
    Balanced Living
    • Exercise & Fitness
    • Gardening
    • Healthy Home
    • Healthy Living
    • Meditation & Inspiration
    • Meet Dr. Weil
    • Pets & Pet Care
    • Technology
    • Wellness Therapies
    Health Centers
    • Aging Gracefully
    • Children
    • Condition Care Guide
    • Men
    • Women
  • Diet & Nutrition
    Diet & Nutrition
    Anti-Inflammatory Diet & Pyramid
    Cooking & Cookware
    Diets & Weight Loss
    Food Safety
    Nutrition
    Recipes
  • Vitamins, Supplements & Herbs
    Vitamins, Supplements & Herbs
    Herbs
    Supplements & Remedies
    Vitamins
  • Ask Dr. Weil
  • Blogs
    Blogs
    Bulletins
    Health Tips
    Spontaneous Happiness
  • Mushrooms
  • Sleep
Press "Enter" to search
Dr. Weil Logo Weil™ Andrew Weil, M.D.
  • Health & Wellness
    Health & Wellness
    Body, Mind & Spirit
    • Addiction
    • Allergy & Asthma
    • Autoimmune Disorders
    • Back Pain
    • Bone & Joint
    • Cancer
    • Colds & Flu
    • Dental & Oral
    • Diabetes
    • Disease & Disorders
    • Ears, Nose, & Throat
    • Feet
    • Gastrointestinal
    • Hair, Skin, & Nails
    • Headache
    • Heart
    • Insects & Parasites
    • Liver & Kidney
    • Mental Health
    • Pregnancy & Fertility
    • Respiratory
    • Sexual Health
    • Sleep Issues
    • Stress & Anxiety
    • Vision
    Balanced Living
    • Exercise & Fitness
    • Gardening
    • Healthy Home
    • Healthy Living
    • Meditation & Inspiration
    • Meet Dr. Weil
    • Pets & Pet Care
    • Technology
    • Wellness Therapies
    Health Centers
    • Aging Gracefully
    • Children
    • Condition Care Guide
    • Men
    • Women
  • Diet & Nutrition
    Diet & Nutrition
    Anti-Inflammatory Diet & Pyramid
    Cooking & Cookware
    Diets & Weight Loss
    Food Safety
    Nutrition
    Recipes
  • Vitamins, Supplements & Herbs
    Vitamins, Supplements & Herbs
    Herbs
    Supplements & Remedies
    Vitamins
  • Ask Dr. Weil
  • Blogs
    Blogs
    Bulletins
    Health Tips
    Spontaneous Happiness
  • Mushrooms
  • Sleep
  • Weil Nutrition Corner
  • Meet Dr. Weil
  • Origins
  • Healthy Aging
  • Marketplace
  • Podcasts
  • Accessibility
  1. Home
  2. Health & Wellness
  3. Body, Mind & Spirit
  4. Mental Health

Kanna: African Herb for Depression?

I am looking into taking the herb kanna to help relieve my anxiety and pretty serious depression. I have tried pharmaceutical antidepressants with bad results.

Andrew Weil, M.D. | July 21, 2011

Market stall herbs and spices for sale near Palace El Badi.
1 min

Kanna (Sceletium tortuosum) has been used in traditional South African medicine for centuries to help boost mood and reduce stress, anxiety and tension. I discussed its use for treating depression with Tieraona Low Dog, M.D., an internationally recognized expert in the fields of integrative medicine, dietary supplements and women’s health, and an expert on botanical medicine. She told me that kanna contains an alkaloid called mesembrine that may act as a serotonin reuptake inhibitor (many commonly prescribed antidepressant medications inhibit the reuptake of serotonin). However, Dr. Low Dog notes that there has not been much research on kanna, and its safety has not been well-established. She says that if she were treating mild depression, she probably would opt for better-studied natural remedies, such as St. John’s wort, SAMe and rhodiola.

I agree with Dr. Log Dog. St. John’s wort is an herbal remedy that has long been used in Europe as a treatment for mood disorders. Standardized extracts have shown an effectiveness equaling that of Prozac for treatment of mild to moderate depression. Don’t take St. John’s wort with anti-retroviral medications, birth control pills, or pharmaceutical antidepressants. The recommended dose is 300 mg of an extract standardized to 0.3 percent hypericin, three times a day. It takes about eight weeks for the full effects to be felt.

SAMe (S-adenosy-L-methionine) has the advantage of working more quickly than St. John’s wort. Use only the butanedisulfonate form in enteric-coated tablets, or in capsules. Try 400-1,600 mg a day on an empty stomach.

Rhodiola is less well-known for treatment of depression, but a study published in 2007 in the Nordic Journal of Psychiatry showed that patients with mild-to-moderate depression who took a rhodiola extract reported fewer symptoms than those who took a placebo.

You also might consider fish oil supplements. Research suggests that the omega-3 fatty acids found in fish oil may help improve and maintain emotional wellness. I recommend 2,000 to 4,000 mg a day of a product providing both EPA and DHA, (eicosapentaenoic acid and docosahexaenoic acid).

Overall, however, the best treatment I know for depression is at least 30 minutes of aerobic exercise daily or at least five days a week.

For a full discussion of natural remedies for depression and an integrative plan for optimum emotional well-being, watch for my new book, Spontaneous Happiness, to be published by Little, Brown & Co. in November of 2011.

Andrew Weil, M.D.

Dr. Weil on Healthy Aging

Start Your 14-Day Free Trial

Free Newsletters

Stay Connected With Dr. Weil

Anti-Inflammatory Diet

Follow Dr. Weil’s Food Pyramid

Get Dr Weils Newsletter Updates

Exclusive Lifestyle, Nutrition & Health Advice

Dr. Weil's FREE health living advice delivered to you!

By clicking "Subscribe," you agree to the DrWeil.com Terms and Conditions and Privacy Policy. You also agree to receive emails from DrWeil.com, and you may opt out of DrWeil.com subscriptions at any time.

Trending Now

10 Ways To A Happier Life | Mental Health | Andrew Weil, M.D.
Mental Health

10 Ways To A Happier Life

A Homeopathic Approach to Depression? | Mental Health | Andrew Weil, M.D.
Mental Health

A Homeopathic Approach to Depression?

A Pill For Loneliness? | Mental Health | Andrew Weil, M.D.
Mental Health

A Pill For Loneliness?

a supplement to boost serotonin
Mental Health

A Supplement to Boost Serotonin?

Dr. Weil Logo Weil™ Andrew Weil, M.D.
Dr. Weil's Signature

Exclusive Lifestyle, Nutrition & Health Advice

  • About Us
  • Press Information
  • Advertising
  • Contact Us
  • Terms of Use
  • Privacy Policy
  • Accessibility

Terms of Use | Privacy Policy

Information on this website is provided for informational purposes only and is not intended as a substitute for the advice provided by your physician or other healthcare professional. You should not use the information on this website for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment. Any third party offering or advertising on this website does not constitute an endorsement by Andrew Weil, M.D. or Healthy Lifestyle Brands.

© Copyright 2025 Healthy Lifestyle Brands, LLC. All rights reserved. Reproduction in whole or in part without permission is prohibited. www.drweil.com