• Weil Nutrition Corner
  • Meet Dr. Weil
  • Origins
  • Healthy Aging
  • Marketplace
  • Podcasts
  • Accessibility
  • Subscribe
Dr. Weil Logo Dr. Weil Logo Weil™ Andrew Weil, M.D.
  • Health & Wellness
    Health & Wellness
    Body, Mind & Spirit
    • Addiction
    • Allergy & Asthma
    • Autoimmune Disorders
    • Back Pain
    • Bone & Joint
    • Cancer
    • Colds & Flu
    • Dental & Oral
    • Diabetes
    • Disease & Disorders
    • Ears, Nose, & Throat
    • Feet
    • Gastrointestinal
    • Hair, Skin, & Nails
    • Headache
    • Heart
    • Insects & Parasites
    • Liver & Kidney
    • Mental Health
    • Pregnancy & Fertility
    • Respiratory
    • Sexual Health
    • Sleep Issues
    • Stress & Anxiety
    • Vision
    Balanced Living
    • Exercise & Fitness
    • Gardening
    • Healthy Home
    • Healthy Living
    • Meditation & Inspiration
    • Meet Dr. Weil
    • Pets & Pet Care
    • Technology
    • Wellness Therapies
    Health Centers
    • Aging Gracefully
    • Children
    • Condition Care Guide
    • Men
    • Women
  • Diet & Nutrition
    Diet & Nutrition
    Anti-Inflammatory Diet & Pyramid
    Cooking & Cookware
    Diets & Weight Loss
    Food Safety
    Nutrition
    Recipes
  • Vitamins, Supplements & Herbs
    Vitamins, Supplements & Herbs
    Herbs
    Supplements & Remedies
    Vitamins
  • Ask Dr. Weil
  • Blogs
    Blogs
    Bulletins
    Health Tips
    Spontaneous Happiness
  • Mushrooms
  • Sleep
Press "Enter" to search
Dr. Weil Logo Weil™ Andrew Weil, M.D.
  • Health & Wellness
    Health & Wellness
    Body, Mind & Spirit
    • Addiction
    • Allergy & Asthma
    • Autoimmune Disorders
    • Back Pain
    • Bone & Joint
    • Cancer
    • Colds & Flu
    • Dental & Oral
    • Diabetes
    • Disease & Disorders
    • Ears, Nose, & Throat
    • Feet
    • Gastrointestinal
    • Hair, Skin, & Nails
    • Headache
    • Heart
    • Insects & Parasites
    • Liver & Kidney
    • Mental Health
    • Pregnancy & Fertility
    • Respiratory
    • Sexual Health
    • Sleep Issues
    • Stress & Anxiety
    • Vision
    Balanced Living
    • Exercise & Fitness
    • Gardening
    • Healthy Home
    • Healthy Living
    • Meditation & Inspiration
    • Meet Dr. Weil
    • Pets & Pet Care
    • Technology
    • Wellness Therapies
    Health Centers
    • Aging Gracefully
    • Children
    • Condition Care Guide
    • Men
    • Women
  • Diet & Nutrition
    Diet & Nutrition
    Anti-Inflammatory Diet & Pyramid
    Cooking & Cookware
    Diets & Weight Loss
    Food Safety
    Nutrition
    Recipes
  • Vitamins, Supplements & Herbs
    Vitamins, Supplements & Herbs
    Herbs
    Supplements & Remedies
    Vitamins
  • Ask Dr. Weil
  • Blogs
    Blogs
    Bulletins
    Health Tips
    Spontaneous Happiness
  • Mushrooms
  • Sleep
  • Weil Nutrition Corner
  • Meet Dr. Weil
  • Origins
  • Healthy Aging
  • Marketplace
  • Podcasts
  • Accessibility
  1. Home
  2. Health & Wellness
  3. Balanced Living
  4. Healthy Living

Do Your Genes Make You Fat?

Can you tell me how much of a role genes play in obesity? If your parents are fat, are you destined to be fat as an adult (or child)? How can you combat obesity if it is in your genes?

Andrew Weil, M.D. | November 8, 2013

An overweight Hispanic woman and a young mixed race Hispanic and Caucasian man exercising together outdoors in an urban setting, running or jogging. They are smiling, looking at each other as they exercise.
2 min

Without question genes play a role in obesity, but the vast majority of cases can’t be blamed on genetic factors. The latest news on this subject comes from Sweden’s Uppsala University, where researchers identified seven new regions – known as loci – of the human genome linked to obesity. They also found that the genetics underlying extreme obesity are similar to those that cause milder forms of overweight and obesity.

More than 260,000 people took part in the Swedish study. Its primary focus was finding as-yet-unidentified genes that increase the risk of obesity as well as comparing genetic factors that cause extreme obesity with those linked to normal weight and being overweight. The researchers clarified that the extremely obese have a greater number of gene variants that apparently may increase the risk of obesity, but they do not have completely different genes from those associated with other weight ranges.

The investigators were able to identify the loci linked to obesity by examining the relationship between different body measurements and 2.8 million gene variants in 168,267 study participants. Then they focused on the 273 gene variants with the strongest links to various body measurements in another 109,703 people. In this way, they were able to confirm the gene loci already known to be associated with various body measurements and to identify four previously unknown gene loci linked to height as well as the seven newly linked to overweight and obesity.

In other research, a study in mice at Boston Children’s Hospital found that a rare genetic mutation kept the animals from efficiently burning off fat calories; the investigators also found a human correlate of this mutation in a group of obese people. Another study in London found that FTO, a specific form of a gene that had previously been linked to obesity, can increase human cravings for high-fat foods.

The more we learn about the genes associated with obesity, the better able we will be to find ways to prevent and treat it. However, experts in the field say that genetic factors are to blame only for about five percent of all cases. Some scientists maintain that even changes in eating and exercise patterns over two decades can’t fully account for the ongoing obesity epidemic and have suggested that chemicals in our environment may share the blame by changing the ways we (and laboratory animals) respond to diet and exercise.

My view is that individuals with a certain genetic constitution can develop insulin resistance if their diets include a lot of carbohydrate foods that carry a high glycemic load. Insulin, the hormone that facilitates the transport of blood sugar (glucose) from the bloodstream into cells throughout the body for use as fuel, is secreted by the pancreas in response to the normal increase in blood sugar that occurs after a meal. With insulin resistance, the normal amount of insulin secreted is not sufficient to move glucose into the cells – thus the cells are said to be “resistant” to its action. To compensate, the pancreas secretes insulin in ever-increasing amounts. This excess insulin drives the body to store fat and influences many other physiologic processes for the worse.

Bottom line: almost all overweight and obese people can lose weight by making healthy changes to their diets and getting regular exercise.

Andrew Weil, M.D.

Dr. Weil on Healthy Aging

Start Your 14-Day Free Trial

Free Newsletters

Stay Connected With Dr. Weil

Anti-Inflammatory Diet

Follow Dr. Weil’s Food Pyramid

Get Dr Weils Newsletter Updates

Exclusive Lifestyle, Nutrition & Health Advice

Dr. Weil's FREE health living advice delivered to you!

By clicking "Subscribe," you agree to the DrWeil.com Terms and Conditions and Privacy Policy. You also agree to receive emails from DrWeil.com, and you may opt out of DrWeil.com subscriptions at any time.

Trending Now

Portrait an unknown male doctor holding a stethoscope behind
Healthy Living

A Better Kind of Medicine?

Young couple is relaxing in the sauna. High angle view.
Healthy Living

A Better Way to Sweat?

Laboratory assistant analyzing a blood sample
Healthy Living

A Dark View of Your Blood?

Meet Dr. Weil: A Healthy Doctor | Andrew Weil, M.D.
Healthy Living

A Healthy Doctor

Dr. Weil Logo Weil™ Andrew Weil, M.D.
Dr. Weil's Signature

Exclusive Lifestyle, Nutrition & Health Advice

  • About Us
  • Press Information
  • Advertising
  • Contact Us
  • Terms of Use
  • Privacy Policy
  • Accessibility

Terms of Use | Privacy Policy

Information on this website is provided for informational purposes only and is not intended as a substitute for the advice provided by your physician or other healthcare professional. You should not use the information on this website for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment. Any third party offering or advertising on this website does not constitute an endorsement by Andrew Weil, M.D. or Healthy Lifestyle Brands.

© Copyright 2025 Healthy Lifestyle Brands, LLC. All rights reserved. Reproduction in whole or in part without permission is prohibited. www.drweil.com