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A Hormone to Promote Weight Loss?
I have heard that the hormone leptin can increase metabolism and reduce fat. Is this true and is it safe to take?
Answer (Published 5/27/2005)

Leptin is a hormone produced by fat cells that appears to play a role in how fat is burned in the body. But exactly what it does and how it works has yet to be completely determined. Researchers at Rockefeller University in New York City, who have extensively studied leptin believe that it informs the brain about the amount of fat in the body, which may in turn influence eating behavior and metabolism. Higher levels of leptin usually are found in overweight or obese people. However, not everyone who is overweight has high leptin levels, which may mean that leptin has a minor or varied role in the development of obesity. And studies at Rockefeller have shown that leptin helps with weight loss in some people but not in others.

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The latest news about leptin comes from a study showing that it triggers production of a peptide called a-MSH in the hypothalamus, the brain area that controls hunger and metabolism. The research team from Brown and Harvard universities that discovered the connection between leptin and a-MSH said that the peptide can boost metabolism by sending a powerful signal to the brain and then to the thyroid gland to increase cellular energy production and burn calories. The study results were published in the early online edition of Proceeding of the National Academy of Sciences for the week of July 26, 2004. The researchers' assumption is that if a drug was available to increase the activity of a-MSH, it would force the body to burn more calories and ultimately lose weight.

I'm aware that products purporting to influence leptin levels in the body are being promoted on the internet and elsewhere, but leptin itself is not available except in research settings. As for the products you can buy, I can't imagine that any of them would affect leptin levels or actually promote weight loss. To my knowledge none of them has been studied and shown to increase leptin levels in the blood. As a matter of fact, some of the products may actually lower leptin levels for a period of time.

Andrew Weil, M.D.

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