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Weil Juvenon Q&A

Help protect and maintain healthy cells - buy Weil Juvenon Healthy Aging Support today.* Join our Monthly Convenience Program to continually promote a healthier, more energetic body.* Money Back Guarantee.

 

What are the most commonly reported benefits of Weil Juvenon Healthy Aging Support?*
The research conducted at Berkeley and elsewhere indicates the main physiologic effect of Weil Juvenon is to promote the healthy functioning of cells.* This includes reducing damaging oxidants, and improving metabolic efficiency*. A central factor in one theory of aging is the breakdown of the mitochondria in your cells. These are the biological engines that convert fats and sugars into energy. Aging mitochondria cannot metabolize as much fuel, so they produce less energy and generate more damaging oxidants.

The most common reported benefits of improved cellular health are:

  • Increased energy, spread evenly throughout the day*
  • Greater mental alertness*

How long will it take to feel results?
People who report physical effects typically feel a difference within 30 days.* Individual responses vary widely, as a result of differences in diet, physical condition, age, and other factors. Sometimes the differences are subtle. Some people, including Juvenon's Scientific Advisory Board Chairman Dr. Bruce Ames, Ph.D., feel little effect but take the product like a vitamin pill, to promote healthy cells and help assure cellular integrity as they age.*

Are there any side effects?
The dosage of the individual substances in the Weil Juvenon Healthy Aging Support has been set well below the amounts used safely in many clinical studies over the past 30 years.* The ingredients in Weil Juvenon Healthy Aging Support are based on substances that are produced naturally in the body.*

Occasionally, some consumers report temporary gastrointestinal effects. For this reason, taking the product with food is recommended. Persons who suffer from gastroesophageal reflux disease (GERD) should consult their healthcare professional. Some people have found that when they take the product with dinner, they feel energized at night and have difficulty falling asleep. Persons who experience this effect may switch to dosing at lunch rather than dinner, or reduce the daily dose. Isolated cases of an allergic reaction, in the form of a rash or hives, have also been reported. Symptoms are reported to have disappeared upon stopping use of the product.

Pregnant women and nursing mothers should avoid taking any supplement not approved by their doctor, including Weil Juvenon Healthy Aging Support, because of a lack of long-term safety data. Persons with diabetes or who are glucose-intolerant should check with their healthcare professional.

What is biotin? Why is it part of the formula?
In April 2004 Weil Juvenon improved the formula of Weil Juvenon Healthy Aging Support* by adding the B vitamin biotin. The amount added is 100 micrograms per tablet, equal to 33% of the Recommended Daily Allowance published by the United States Government. Biotin is required in a number of biochemical reactions, including those involving fat and carbohydrate metabolism. It is important for maintaining optimal levels of metabolites utilized for energy production in the mitochondria. It also contributes to maintaining healthy skin, hair and nervous system*.

The molecular structure of biotin is similar to that of alpha lipoic acid, one of the principal ingredients in Weil Juvenon Healthy Aging Support.* As a consequence of this structural similarity, an excess of alpha lipoic acid can compete with or displace biotin from its cognate enzyme, according to experimental evidence from cell and animal studies. For this reason, biotin has been added to offset a potential imbalance.

Can I take this product with prescription drugs?
Persons undergoing chemotherapy or taking anti-diabetes drugs should check with their doctor. Before taking any dietary supplement and prescription drug simultaneously, it's always a good idea to consult with your healthcare professional.

Can I take Weil Juvenon Healthy Aging Support along with my regular vitamins?
Yes. Weil Juvenon's Scientific Advisory Board recommends that healthy adults take a daily multivitamin, in addition to their regular Weil Juvenon dose. The alpha lipoic acid in Weil Juvenon Healthy Aging Support does recycle several antioxidants, including vitamins C and E, as well as glutathione and some others. However, it is not necessary to cut back on your vitamin C or E as long as you are taking less than 1,000 IU of vitamin E per day. Most of the excess vitamins, especially those that are water soluble, are eliminated by the kidney.

Is this product FDA-approved?
No. Weil Juvenon Healthy Aging Support* is sold in accordance with the Dietary Supplement Health and Education Act, passed by Congress in 1994. This Act allows marketing of dietary supplements without prior approval by the U. S. Food and Drug Administration (FDA). The FDA exerts general oversight over product safety and supervises the marketing claims made for dietary supplements once they are already on the market.

At what age should one start taking Weil Juvenon Healthy Aging Support?*
Just about anyone can benefit. People over 50 appear to have more remarkable improvements, but the intensity of the reported benefits varies from individual to individual, depending on their health, genetics, lifestyle and diet. Therefore, people in their forties or even younger could very well experience a significant beneficial effect from Weil Juvenon Healthy Aging Support.*

Why do you recommend taking Weil Juvenon Healthy Aging Support* with food?
We state on the bottle to take with food simply because an occasional person will experience a slight upset stomach when the product is taken without food. Weil Juvenon Healthy Aging Support is absorbed more directly into the bloodstream when it is taken on an empty stomach.*

What does the FDA advise with regard to evaluating and buying dietary supplements?
The FDA offers "Tips for the Savvy Supplement User" at http://vm.cfsan.fda.gov/~dms/ds-savvy.html.

What precautions, adverse reactions and contraindications for each of the major ingredients in Weil Juvenon Healthy Aging Support* have been reported in scientific literature?
Pregnant and lactating women are advised not to consume either acetyl-L-carnitine or alpha lipoic acid, because of lack of long-term safety data.

With regard to acetyl-L-carnitine, the Supplement Monographs published by the Physicians Desk Reference (PDR), a well-known reference handbook, indicate that no contraindications are known. Adverse reactions reported by the PDR include mild gastrointestinal symptoms, including nausea, vomiting, and abdominal cramps, as well as headache. Other sources report an increase in agitation or restlessness. An increase in seizure frequency has been reported in persons with seizure disorder. Persons with Alzheimer's disease may exhibit psychiatric disturbances, such as depression and confusion, but it is uncertain whether these effects are due to acetyl-L-carnitine or the disease itself. Some evidence suggests acetyl-L-carnitine may interfere with thyroid metabolism.

Oral alpha lipoic acid is reported in the literature to be well tolerated in doses up to 600 milligrams per day. The PDR reports that no contraindications are known and there are no reports of overdosage. Alpha lipoic acid is used in Germany to treat diabetic neuropathy and liver disorders in doses of 1,200 milligrams daily or 600 milligrams three times per day. Persons with diabetes should consult a physician, since supplementation with alpha lipoic acid may lower blood glucose levels. Skin rash has been reported in connection with oral alpha lipoic acid. Some evidence suggests that high doses of alpha lipoic acid may contribute to thiamin deficiency (a condition associated, for example, with alcoholism).

How do you ensure the quality of Weil Juvenon Healthy Aging Support*?
Weil Juvenon Healthy Aging Support* tablets are made in the U.S.A, in a high-tech manufacturing plant that is registered with the Federal Government and the State of California to manufacture drugs. It is also licensed by the Drug Enforcement Agency to manufacture precursors of methamphetamines. Of course, Weil Juvenon Healthy Aging Support is a dietary supplement, not a drug, but these licenses are indicative of the strict quality requirements that prevail in the plant.

The plant has also passed a rigorous quality inspection administered by the United States Pharmacopoeia (USP), which provides manufacturing standards for more than 3,800 medicines, dietary supplements, and other healthcare products. The National Nutritional Foods Association has audited the plant and certified that it meets the rigorous standards of Good Manufacturing Practices (GMP).

The raw materials used in Weil Juvenon products are received with Certificates of Analysis that certify their composition. The raw materials, as well as the packaging materials, are subjected to rigorous quality testing before they are accepted into the plant. Throughout the manufacturing process, written Standard Operating Procedures (SOPs) govern every step.

The stability of Weil Juvenon Healthy Aging Support* tablets has been studied under a variety of conditions of temperature and stability, using methods specified by the USP. Expiration dates, established in accordance with the stability testing results, are stamped on the bottom of each bottle.

Does Weil Juvenon Healthy Aging Support* contain the R+ isomer or enantiomer of lipoic acid, or the racemic mixture?
Stereoisomers or enantiomers are different compounds with the same molecular formula and physical and chemical properties. Lipoic acid has R and S enantiomers, which are mirror images of each other. Consequently, the 3-D structure of the two is different, due to variation in molecular arrangement in space. Because of this variation one form, the R, rotates polarized light to the right, while the S form rotates it to the left.

The alpha lipoic acid present in the Weil Juvenon Healthy Aging Support* is called a racemic mixture and contains an equal mixture of R and S. The R form is the one that is synthesized by the body. The R form is the isomer utilized by the enzymes of the mitochondria for the conversion of food metabolites to energy. However, the S form does have antioxidant activity, and does not appear to interfere significantly with the R form, although this is not entirely clear.

Virtually all of the human studies to date (going back some 35 years) have utilized the racemic mixture, which is more stable and considerably less expensive. It is not known whether the R form is in fact more beneficial to humans than the racemic mixture. In spite of claims by some that the S form interferes with the R form, there is no experimental evidence to support this statement. In fact, there is no evidence to date that demonstrates unequivocally that the R form is superior to the R/S mixture in promoting cellular health.

Weil Juvenon scientists continue to evaluate this question. When and if peer-reviewed research establishes that the R form, without the S, is a superior protector of cellular health in humans, Weil Juvenon will offer a product containing only the R form.

Why do you use acetyl-L-carnitine rather than L-carnitine?
Acetyl-L-carnitine has the following properties lacking from L-carnitine, which makes this form of carnitine the choice for Weil Juvenon Healthy Aging Support*:

  • Crosses the blood-brain barrier more readily*
  • Taken up by cells and enter the mitochondria more readily*
  • Can function as a donor of the acetyl group to choline to produce the neurotransmitter, acetylcholine*
  • Is more effective than L-carnitine in neuroprotection.

Why is lipoic acid more appropriate for use with acetyl-L-carnitine than other antioxidants?
Lipoic acid was chosen as the antioxidant because it functions in concert with acetyl-L-carnitine in energy production and the synthesis of the neurotransmitter, acetylcholine. Both lipoic acid and acetyl-L-carnitine are produced by the cell and present in the mitochondria. Lipoic acid is also one of the more potent natural antioxidants present in the body with the ability to protect both lipid and water-soluble components.*

What is the benefit of taking Weil Juvenon Healthy Aging Support* rather than buying the ingredients separately?
The benefit of taking Weil Juvenon Healthy Aging Support* over mixing your own concoction is based on several facts. The ratio of the compounds in Weil Juvenon Healthy Aging Support* was carefully chosen and was based on human studies. The ingredients in our tablet were formulated to work in concert and are manufactured in accordance with strict quality controls. For the consumer, the convenience of taking both compounds at the optimum ratio in one tablet is also important.

Is there anything in Weil Juvenon Healthy Aging Support* that is of animal derivation? Anything that is the product of a genetically modified organism?
Weil Juvenon Healthy Aging Support* contains no animal-derived products and no genetically modified organisms, nor is it produced from genetically modified organisms.

Does Weil Juvenon Healthy Aging Support* contain any major food allergens?
The Food Allergen Labeling and Consumer Protection Act (FALCPA) defines a "major food allergen" as any one of the following ingredients: milk, egg, fish, Crustacean shellfish, tree nuts, wheat, peanuts, and soybeans. Products labeled after January 1, 2006 must identify any major food allergen. The Weil Juvenon formula currently contains only one "major food allergen:" lecithin soya, which is identified on the label. The label on Weil Juvenon bottles manufactured in 2005 contains the wording "No Common Allergen" (and also lists lecithin soya). "No Common Allergen" has been removed from the label on product manufactured in early 2006.

Weil Juvenon has recently modified the formula to exclude lecithin soya. For this reason, "No Common Allergen" will soon reappear on the label.

What are the dietary sources of acetyl-L-carnitine and alpha lipoic acid?
The principal dietary source of acetyl-L-carnitine is red meat. The highest concentrations are found in mutton. Alpha lipoic acid is present in both plants and animals and is an integral component of the photosynthetic process of chloroplasts. Very small quantities of lipoic acid are contained in dietary sources such as spinach. Nevertheless, it is virtually impossible to meet one's need for alpha lipoic acid through dietary intake.

How did you determine the dose of Weil Juvenon Healthy Aging Support*? Is one dose appropriate for everyone?
We looked at dozens of clinical studies carried out in Europe and the U.S. over the past 30 years, using each of our key ingredients separately in a wide range of doses. After determining the levels at which the ingredients are well tolerated, we evaluated efficacy parameters, including mental alertness and attitudes, sense of well-being, energy level, and sleep patterns.*

Our recommendation of 2 tablets/day is based on numerous human studies with the individual ingredients in Weil Juvenon, in which the responses were examined over a range of doses. Our ancedotal experience is that 2/day is optimal for more than 75% of people. However, some individuals find they obtain a more pronounced effect with a somewhat higher dose (up to 3 or even 4/day) and a few people prefer 1/day. The variation in response to the different doses is clearly related to differences in metabolism and reflects human genetic variability.

What about Weil Juvenon for pets?
Consult with your veterinarian before giving any compound to your companion animals. The compounds in the Juvenon formula have been demonstrated to have positive effects on both mental and physical activities in laboratory animals. There is also experimental evidence (both in vivo and in vitro) indicating that the compounds in the supplement help to protect tissues by inhibiting the production of tissue-damaging free-radicals. The tissues protected include skeletal muscle, heart, liver, and tissue comprising the nervous system. The majority of these studies were with dogs and rodents. Unlike dogs and many other animals, cats cannot tolerate the Weil Juvenon product because they are sensitive to one of the active compounds, alpha lipoic acid. The metabolism of lipoic acid by the cat's liver is very different from that of other animals, and results in liver toxicity. Therefore, Weil Juvenon is not recommended for cats.*

Recommended dose: 1 tablet/ 50 lb/day or 1/4 tablet/12 lbs/day. This dose can be applied to dogs, hamsters and other rodents, and horses.

Help protect and maintain healthy cells - buy Weil Juvenon Healthy Aging Support today.* Join our Monthly Convenience Program to continually promote a healthier, more energetic body.* Money Back Guarantee.


 

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

For medical advice, please consult a properly trained healthcare practitioner.

Weil Juvenon, Weil Juvenon Cellular Health Supplement, Weil Juvenon Energy Formula and the Weil Juvenon logo are among the trademarks of Juvenon, Inc.


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